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23 andme Prueba de ADN – Salud + ancestry Servicio de genética Personal – 75 + informes en línea 23andMe: Salud y Hogar

(20 customer reviews)

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20 reviews for 23 andme Prueba de ADN – Salud + ancestry Servicio de genética Personal – 75 + informes en línea 23andMe: Salud y Hogar

  1. Coastal Girl

    The testing is fairly simple: You receive a test vial (log in and register it on their website) and provide saliva up to the control line. Make sure you don’t eat or drink for 30 to 45 minutes before providing your saliva sample. It is best not to brush teeth beforehand since it will only wash away valuable DNA and you want to ensure your sample has enough to process. Yes I had a few failed kits in my life and that set us back months of getting results on those kits. Anyway it’s fairly simple to provide saliva samples. Simple enough I had my 5 1/2 year old done and she was the easiest one to process. Then you place the kit back into included return envelope and wait for about 6 to 8 weeks for it to process. All while keeping tabs of the process online as each step finishes.I started using 23andme in 2012 before the FDA had gotten nasty and demanded they stop providing such detailed health analysis. Most of the kits I purchased (all but 2) included the ancestry with health but the ancestry portion was the sole purpose for us using 23andme services. I have tested both of my parents, my two children, two paternal aunts, my daughter’s paternal grandmother as well as myself and two cousins whom I tested to confirm our relationship. If you test at least one parent, you can easily sort matches that are shared with that parent to determine which matches are maternal and paternal. Since both my parents have tested mine literally shows who matches me from each side and my children can sort their matches based on me being tested too.My paternal grandfather died in 1995 and took with him the secret of his past. He had ran away as a young boy and changed his name so we knew him only by the name he had taken. My family always yearned to know more about my grandfather’s past but he had endured some sort of trauma or something and for whatever reason chose to never speak of it again. So we grew up only knowing half my father’s ancestry – that of his mother.After my grandfather died, I set out on a mission to try to figure out more about his past and his identity. I sent off for birth and school records and hit one dead-end after another trying to prove he was who he said he was. I spent hours going over census data on Ancestry’s website, writing to courthouses across the country. The evidence pointed to the conclusion he was not who he said he was and so I had nothing solid to go by. Until 17 years into chasing cold trails, I discovered ancestry type DNA testing. I figured it wouldn’t hurt to order my dad a kit and see where that would take us. If I could just find one close enough match then maybe it would give us a good lead on figuring out my grandfather’s real surname.After waiting for what seemed like months (it was actually only about 6 weeks) my dad’s DNA was online (on 23andme’s secure site) and accessible along with all his many matches – which were basically cousins at various degrees of distance. It was one cousin (a predicted second cousin) in particular that gave me access to their family tree and actually dove in with me searching for clues that would lead us to my grandfather.Just 6 months into researching my father’s DNA, I found my grandfather’s family and figured out who he really was. I wanted to ensure that my information was correct and so I contacted the daughters to the man I believed to be my grandfather’s brother and offered to test them both. Their test results confirmed they were indeed our 1st cousins. I have since been in contact with close and distant family via this newly discovered paternal side and even obtained a copy of my grandfather’s family surname book. His absence was even recorded in the book! I solved an 83+ year mystery and gained a family I longed my entire life to know about. I cannot be more thankful that these tests are available and that it gives us such ability to solve things that seem impossible.Granted this all sounds way easier than it was and in all honesty it took planning and sorting and meticulous record-keeping to rule out my father’s maternal matches. I literally mapped my father’s DNA and researched every match labeling in an Excel document, which chromosome location that relative fit and what surnames fit within those matches. It’s given me new found respect and interest in knowing about each and every ancestor that left their mark within our DNA. It’s time-consuming, rewarding and addicting. I can say that with all honesty as I now manage 15+ kits on various DNA web sites. I tested myself and both parents on 23andme as well as AncestryDNA and Dad was also tested on FTDNA but I met my most useful matches on 23andme. It was on 23andme that I found the best ability to pour over chromosomes researching every detail I could.Oddly between 23andme and Ancestry their tests show a discrepancy in ethnicity estimates. One shows that my dad has a tiny trace of Native American (23andme) yet AncestryDNA does not show any trace whatsoever of Native American. My son has confirmed Native American and was only tested on 23andme and his percentage came back at nearly exact what is on his BIA blood quantum card. So I lean in feeling more comfortable with 23andme’s ethnicity estimates.IMPORTANT TO NOTE: You can take your raw data (once your DNA is processed) and download it from any of these DNA testing sites and upload them for free to GEDmatch. That site allows you to cross compare other matches on there from all the DNA sites. As long as others have their data on their too you can look at those matches and even see where the match is on individual chromosomes, etc. It’s a great tool to utilize along with your DNA testing sites.FINAL THOUGHT: If you are looking to solve a mystery, 23andme is great. If you are looking to just fill in a family tree and you have a paid Ancestry membership or you are willing to pay for it, I would also suggest AncestryDNA. AncestryDNA gives you immediate access to your matches’ trees and you can in turn build on your own tree with the information. But if you are NOT a paid member to Ancestry, their AncestryDNA features are limited. I personally think its poor business practice for Ancestry to force people who already fork over money for the DNA kits to further pay to utilize services that should be totally included within the purchase of the kit. With 23andme, there are no additional hidden usage fees.Whichever one you choose, be prepared to discover a new you.

  2. Coastal Girl

    The testing is fairly simple: You receive a test vial (log in and register it on their website) and provide saliva up to the control line. Make sure you don’t eat or drink for 30 to 45 minutes before providing your saliva sample. It is best not to brush teeth beforehand since it will only wash away valuable DNA and you want to ensure your sample has enough to process. Yes I had a few failed kits in my life and that set us back months of getting results on those kits. Anyway it’s fairly simple to provide saliva samples. Simple enough I had my 5 1/2 year old done and she was the easiest one to process. Then you place the kit back into included return envelope and wait for about 6 to 8 weeks for it to process. All while keeping tabs of the process online as each step finishes.I started using 23andme in 2012 before the FDA had gotten nasty and demanded they stop providing such detailed health analysis. Most of the kits I purchased (all but 2) included the ancestry with health but the ancestry portion was the sole purpose for us using 23andme services. I have tested both of my parents, my two children, two paternal aunts, my daughter’s paternal grandmother as well as myself and two cousins whom I tested to confirm our relationship. If you test at least one parent, you can easily sort matches that are shared with that parent to determine which matches are maternal and paternal. Since both my parents have tested mine literally shows who matches me from each side and my children can sort their matches based on me being tested too.My paternal grandfather died in 1995 and took with him the secret of his past. He had ran away as a young boy and changed his name so we knew him only by the name he had taken. My family always yearned to know more about my grandfather’s past but he had endured some sort of trauma or something and for whatever reason chose to never speak of it again. So we grew up only knowing half my father’s ancestry – that of his mother.After my grandfather died, I set out on a mission to try to figure out more about his past and his identity. I sent off for birth and school records and hit one dead-end after another trying to prove he was who he said he was. I spent hours going over census data on Ancestry’s website, writing to courthouses across the country. The evidence pointed to the conclusion he was not who he said he was and so I had nothing solid to go by. Until 17 years into chasing cold trails, I discovered ancestry type DNA testing. I figured it wouldn’t hurt to order my dad a kit and see where that would take us. If I could just find one close enough match then maybe it would give us a good lead on figuring out my grandfather’s real surname.After waiting for what seemed like months (it was actually only about 6 weeks) my dad’s DNA was online (on 23andme’s secure site) and accessible along with all his many matches – which were basically cousins at various degrees of distance. It was one cousin (a predicted second cousin) in particular that gave me access to their family tree and actually dove in with me searching for clues that would lead us to my grandfather.Just 6 months into researching my father’s DNA, I found my grandfather’s family and figured out who he really was. I wanted to ensure that my information was correct and so I contacted the daughters to the man I believed to be my grandfather’s brother and offered to test them both. Their test results confirmed they were indeed our 1st cousins. I have since been in contact with close and distant family via this newly discovered paternal side and even obtained a copy of my grandfather’s family surname book. His absence was even recorded in the book! I solved an 83+ year mystery and gained a family I longed my entire life to know about. I cannot be more thankful that these tests are available and that it gives us such ability to solve things that seem impossible.Granted this all sounds way easier than it was and in all honesty it took planning and sorting and meticulous record-keeping to rule out my father’s maternal matches. I literally mapped my father’s DNA and researched every match labeling in an Excel document, which chromosome location that relative fit and what surnames fit within those matches. It’s given me new found respect and interest in knowing about each and every ancestor that left their mark within our DNA. It’s time-consuming, rewarding and addicting. I can say that with all honesty as I now manage 15+ kits on various DNA web sites. I tested myself and both parents on 23andme as well as AncestryDNA and Dad was also tested on FTDNA but I met my most useful matches on 23andme. It was on 23andme that I found the best ability to pour over chromosomes researching every detail I could.Oddly between 23andme and Ancestry their tests show a discrepancy in ethnicity estimates. One shows that my dad has a tiny trace of Native American (23andme) yet AncestryDNA does not show any trace whatsoever of Native American. My son has confirmed Native American and was only tested on 23andme and his percentage came back at nearly exact what is on his BIA blood quantum card. So I lean in feeling more comfortable with 23andme’s ethnicity estimates.IMPORTANT TO NOTE: You can take your raw data (once your DNA is processed) and download it from any of these DNA testing sites and upload them for free to GEDmatch. That site allows you to cross compare other matches on there from all the DNA sites. As long as others have their data on their too you can look at those matches and even see where the match is on individual chromosomes, etc. It’s a great tool to utilize along with your DNA testing sites.FINAL THOUGHT: If you are looking to solve a mystery, 23andme is great. If you are looking to just fill in a family tree and you have a paid Ancestry membership or you are willing to pay for it, I would also suggest AncestryDNA. AncestryDNA gives you immediate access to your matches’ trees and you can in turn build on your own tree with the information. But if you are NOT a paid member to Ancestry, their AncestryDNA features are limited. I personally think its poor business practice for Ancestry to force people who already fork over money for the DNA kits to further pay to utilize services that should be totally included within the purchase of the kit. With 23andme, there are no additional hidden usage fees.Whichever one you choose, be prepared to discover a new you.

  3. Michael Tran

    Pretty nifty. I’m a molecular biologist and this is good ignored you want health traits. It’s not that great if you want Ancestry, such as finding more relatives. For that, I did Ancestry and ended up finding my grandpa.Traits are cool and the new FDA approved health ones are awesome to see if you are predisposed to BRCA1 or 2 mutations. It’s also cool that you can have a friends list on their website (list of shared DNA).This process is just known as genotyping for single nucleotide polymorphisms. It’s not sequencing so don’t be confused. Still, then jnformation is good to share with your Doc or PA if you want more professional healthcare advice. FDA is pretty critical when it comes to these tests, so give them faith at about 99%, however, just because you have 1 SNP, does not mean you’re doomed or your kids are doomed.Phenotype = genotype + environment, not just genotype

  4. Michael Tran

    Pretty nifty. I’m a molecular biologist and this is good ignored you want health traits. It’s not that great if you want Ancestry, such as finding more relatives. For that, I did Ancestry and ended up finding my grandpa.Traits are cool and the new FDA approved health ones are awesome to see if you are predisposed to BRCA1 or 2 mutations. It’s also cool that you can have a friends list on their website (list of shared DNA).This process is just known as genotyping for single nucleotide polymorphisms. It’s not sequencing so don’t be confused. Still, then jnformation is good to share with your Doc or PA if you want more professional healthcare advice. FDA is pretty critical when it comes to these tests, so give them faith at about 99%, however, just because you have 1 SNP, does not mean you’re doomed or your kids are doomed.Phenotype = genotype + environment, not just genotype

  5. T Stanley

    I bought this with Prime and it took exactly 2 weeks from the moment I clicked “buy” until my reports were published. I may be one of the lucky ones but I think it is because I bought the kit April 20 2018 – so it wasn’t during any holiday rush periods. From reviews, I would hesitate buying this around Christmas time if you aren’t patient – they seem to get slammed and delays seem normal.This and Ancestry.com seems to be the top 2 kits in most comparison reviews. Ancestry for heritage related results due to larger database & this for health related results. I chose this one because of the health related results and because Ancestry requires extra costs to integrate DNA results into their extensive database. Ancestry does not offer health related results to my knowledge but I think you can export the data into 3rd party tools to get those results.One note of warning – there are kits on ebay that are a bit cheaper but most of those do not include the lab work – and I’ve not seen any that were cheaper than buying the kit with lab on Amazon. Read the fine print if you look on ebay.2nd note of warning – I wouldn’t do this at all if you are concerned about your DNA being hacked and shared. There are reports on Internet that FBI is searching these databases for criminals – and if you believe the government is able to secure secrets the way x-files portrays, then maybe it’s safe forever. Personally, I can’t think of any realistic consequence to my DNA being shared that outweighs the benefit of knowing my DNA. If I get tied up in a lab so they can harvest my stem cells because I’m the beginning of an x-men mutation, I guess I’ll have plenty of time to think about my decision.The kit itself is very simple. Once you receive the kit (2 days with prime) and before you collect specimen (saliva), you open an account with 23andMe and enter the code off the vial in the kit. You will make some decisions about the process at that point – such as if you want your data used for research and if they can keep your dna samples for future use, etc. Once that is done, you will need to clean your mouth very well and not eat/drink for an hour or so before spitting into the vial. I cleaned my mouth very well before going to bed, drank a big glass of water when I woke (so I could spit easily), and waited an hour and filled the vial. Spit until clear saliva is just above the indicated line – the bubbles will all be floating above that line. It doesn’t take much and you don’t want to overfill it by much or you may not have enough stabilizer for the amount of saliva. The vial initially has a funnel on the top that you close the lid and it will release the stabilizer into the vial. Once you have stabilizer in saliva, remove the funnel and replace it with the round cap. Shake it well and put the sealed vial into the included baggie. Box it back into the original box which is addressed and has prepaid postage – ship it off. I had mine back in the mail on the 3rd day after ordering.I used the iphone app at this point. The app tracks progress of each step. It didn’t show the post office received the package, but in 2 days or so the status jumped to the vial being received and being pre-checked. Each step seemed to complete about 2 – 3 days apart until the reports became available.Be sure to switch to a computer at some point. It either has more options, or they are easier to find there – especially where contacting others is concerned.I am no DNA expert, but the results are interesting to read over. It found my niece who took the test successfully and correctly identified her in my lineage. She had shared her ancestry results so people could find her. Contacting matches is easy with the messenger in the online tool.I think the results I’ve seen are pretty accurate – some of the expected traits are off – it seems to do better with hair, eye color and skin tone than things like attached/detached earlobes and which finger is longer. Since some of those are wrong, I’m not sure there is much more value in that than going to an old gypsy woman looking into a glass ball but it’s entertaining to see the predictions. Recognize you can export the raw data into other tools – Prometheus seems to be most popular – to have reports run to interpret the data. 23andMe seems to keep things at a level that is more manageable. I only exported to Prometheus which is about $5 to $10 usually, but free for this week. If you really get into this stuff, I think it’s worthwhile to see those results, but Prometheus gets a little confusing because you can have one result reducing your risk for something by some multiplier and another increasing your risk for it. Do they cancel out? 23andme tends to just tell you increased or decreased risk.Where I think this is weak – is for determining Native American ancestry. If that is your goal, you may want to research DNA accuracy for that before spending your money. My research shows that getting matches on that must be fairly close to the ancestors – mine showed none in my lineage. My grandmother always said she was part Indian and she looked the part so I tend to believe her. It wasn’t until I found no matches that I started researching why – and it sounds like it is common for that to be missed by most DNA ancestry kits.My overall thoughts – I question the accuracy of some risks indicated – I just don’t think we are really there yet. I personally think one can only say labs see this sort of trend when this strand is found. Prometheus shows relationships for genes and medicines that may not metabolize properly for me. I am capturing that to discuss with my doctor – just in case. The ancestry part does work reliably to find relatives and seems to be fairly accurate to place them where they branch off from your family tree.

  6. T Stanley

    I bought this with Prime and it took exactly 2 weeks from the moment I clicked “buy” until my reports were published. I may be one of the lucky ones but I think it is because I bought the kit April 20 2018 – so it wasn’t during any holiday rush periods. From reviews, I would hesitate buying this around Christmas time if you aren’t patient – they seem to get slammed and delays seem normal.This and Ancestry.com seems to be the top 2 kits in most comparison reviews. Ancestry for heritage related results due to larger database & this for health related results. I chose this one because of the health related results and because Ancestry requires extra costs to integrate DNA results into their extensive database. Ancestry does not offer health related results to my knowledge but I think you can export the data into 3rd party tools to get those results.One note of warning – there are kits on ebay that are a bit cheaper but most of those do not include the lab work – and I’ve not seen any that were cheaper than buying the kit with lab on Amazon. Read the fine print if you look on ebay.2nd note of warning – I wouldn’t do this at all if you are concerned about your DNA being hacked and shared. There are reports on Internet that FBI is searching these databases for criminals – and if you believe the government is able to secure secrets the way x-files portrays, then maybe it’s safe forever. Personally, I can’t think of any realistic consequence to my DNA being shared that outweighs the benefit of knowing my DNA. If I get tied up in a lab so they can harvest my stem cells because I’m the beginning of an x-men mutation, I guess I’ll have plenty of time to think about my decision.The kit itself is very simple. Once you receive the kit (2 days with prime) and before you collect specimen (saliva), you open an account with 23andMe and enter the code off the vial in the kit. You will make some decisions about the process at that point – such as if you want your data used for research and if they can keep your dna samples for future use, etc. Once that is done, you will need to clean your mouth very well and not eat/drink for an hour or so before spitting into the vial. I cleaned my mouth very well before going to bed, drank a big glass of water when I woke (so I could spit easily), and waited an hour and filled the vial. Spit until clear saliva is just above the indicated line – the bubbles will all be floating above that line. It doesn’t take much and you don’t want to overfill it by much or you may not have enough stabilizer for the amount of saliva. The vial initially has a funnel on the top that you close the lid and it will release the stabilizer into the vial. Once you have stabilizer in saliva, remove the funnel and replace it with the round cap. Shake it well and put the sealed vial into the included baggie. Box it back into the original box which is addressed and has prepaid postage – ship it off. I had mine back in the mail on the 3rd day after ordering.I used the iphone app at this point. The app tracks progress of each step. It didn’t show the post office received the package, but in 2 days or so the status jumped to the vial being received and being pre-checked. Each step seemed to complete about 2 – 3 days apart until the reports became available.Be sure to switch to a computer at some point. It either has more options, or they are easier to find there – especially where contacting others is concerned.I am no DNA expert, but the results are interesting to read over. It found my niece who took the test successfully and correctly identified her in my lineage. She had shared her ancestry results so people could find her. Contacting matches is easy with the messenger in the online tool.I think the results I’ve seen are pretty accurate – some of the expected traits are off – it seems to do better with hair, eye color and skin tone than things like attached/detached earlobes and which finger is longer. Since some of those are wrong, I’m not sure there is much more value in that than going to an old gypsy woman looking into a glass ball but it’s entertaining to see the predictions. Recognize you can export the raw data into other tools – Prometheus seems to be most popular – to have reports run to interpret the data. 23andMe seems to keep things at a level that is more manageable. I only exported to Prometheus which is about $5 to $10 usually, but free for this week. If you really get into this stuff, I think it’s worthwhile to see those results, but Prometheus gets a little confusing because you can have one result reducing your risk for something by some multiplier and another increasing your risk for it. Do they cancel out? 23andme tends to just tell you increased or decreased risk.Where I think this is weak – is for determining Native American ancestry. If that is your goal, you may want to research DNA accuracy for that before spending your money. My research shows that getting matches on that must be fairly close to the ancestors – mine showed none in my lineage. My grandmother always said she was part Indian and she looked the part so I tend to believe her. It wasn’t until I found no matches that I started researching why – and it sounds like it is common for that to be missed by most DNA ancestry kits.My overall thoughts – I question the accuracy of some risks indicated – I just don’t think we are really there yet. I personally think one can only say labs see this sort of trend when this strand is found. Prometheus shows relationships for genes and medicines that may not metabolize properly for me. I am capturing that to discuss with my doctor – just in case. The ancestry part does work reliably to find relatives and seems to be fairly accurate to place them where they branch off from your family tree.

  7. R. Holzle

    Oct 2019 Update revises Promethease recommendation; Oct 2018 Update adds Alzheimer comments.I had DNA analysis from 23andme. My wife had DNA analysis from both Ancestry(Anc) and 23andme. This review is my comparison of the two. I now do not recommend secondary analysis of your results by Promethease, see further discussion at end of this review. Basically I like 23andme. For developing an ancestry tree, Ancestry.com is MUCH better IF you signup separately for Ancestry’s subscription search service. Do not use Anc & Promethease for Alzheimer’s – see discussion at end of this review.TAKING TEST and SIGNUP – Very similar test taking. 23’s signup was more secure. Anc’s was easier, but they automatically put my wife’s test on my previously existing Ancestry account.Waiting on RESULTS – Both send emails confirming sample receipt and when results were available. After logon, 23 provided step by step progress reports on the analysis process. The analysis process itself took about 10 days, including a holiday weekend. Total wait time was 3-4 weeks. Anc took 5 or so days longer than 23.WEB SITE SECURITY – 23 is better. 23 requires a typical logon and password to get to the site. Anc automatically remembers your logon and password and just opens up when you go to the site. However, actually downloading your DNA file from Anc requires a full sign-on and confirmation link via your e-mail..Ethnic Origin Analysis – I think 23 is more correct. Both 23 and Anc keep updating their Ethnic origin results. Note the results are only approximate considering the accuracy ranges provided.DNA RELATIVE IDENTIFICATION – Recognizing that allocation of relatives to 1st, 2nd and 3rd cousins is somewhat imprecise. For my wife, 23 identified 4 second cousins and about 32 third cousins. Anc identified 1 first cousin, 2 second cousins and 9 third cousins. 23 also has ‘cousins’ outside the USA (in my case in the UK) which are really valuable contacts for ancestry searching. The web site does not directly identify a cousin’s location but you can easily guess this from supplementary info optionally provided by the cousin on 23’s site.DNA RELATIVE CONTACT and ANALYSIS – Anc provides the e-mail for a contact and shared ancestors for each DNA relative. You get a lot more when you pay for their regular Ancestry services, see below. 23 provides an internal messaging application for communicating with contacts. The application works but is rudimentary and unsuitable for more than brief messages (especially with MS Edge); exchanging e-mail address’s after contact is more satisfying. Both have a couple levels of ‘sharing’ (aka privacy). Both have tools for grouping contacts.Anc provides a powerful tree searching tool IF you subscribe to the regular Ancestry service. This is expensive, in the range of $200/year, but less with special offers. Given the moderate ‘tools’ in their basic DNA service, I view their DNA analysis as an (effective) teaser for their subscription service. UPDATE: I did signup for the Ancestry services and they are great. Specifically, with a subscription their DNA site shows a contacts pedigree chart if that contact already has built an Anc family tree. This is MASSIVELY better than 23’s unsorted list of surnames. When you search for a particular name it searches all of the connected family trees – this is exceptionally useful.MEDICAL INFO – Anc provides no medical info. In late 2016 23 had two test options – $100 for just the ancestry service and $200 for ancestry plus medical. As of Sept 2018, 23 provides FDA approved reports on your risk of 9 medical conditions, including Alzheimer’s, plus several genetic carrier reports. Their discussion/explanation of your risks for these conditions is specifically approved by the FDA and is understandable, informative, and useful. [Update ANC now advertises health results – I have not tried this]If you are so inclined, you can participate (answer a lot of online questions) in 23’s medical research. This is probably 20 ten minute questions sessions. I did this and feel like it was useful for medical research.Analysis of you DNA results by Promethease, a third party service, provides some medical info.[October 2019 Update] In late 2019 Promethease was bought by MyHeritage, an Israeli Company. They have advised that they will use the DNA profiles downloaded to them for DNA ancestry searches, including searches by police departments. I personally am uncomfortable with this. Further in early 2019 Promethease stopped providing reports for a number of SNP’s potentially related to drug usage, apparently due to pressure from the FDA. These are among the MOST useful (actionable) results. For these reasons I think Promethease is now of substantially less value. Perhaps MyHeritage will reinstate the deleted SNP’s, but I doubt it. Use Promethease with caution. Note that I have NOT updated the remainder of the Prom discussion to reflect the above comments.CONNECTION to PROMETHEASE – Promethease (Prom) is a third party service that assess’s your detailed DNA results from either 23 or Anc and provides a detailed medical risk report. Go to the Prom site to get started. The download process is not too difficult. In Oct 2018 cost is $12 per report.PROMETHEASE RESULTS –Prom generates 20,000 or so reports (hits) from the 700,000 or so genes that are tested by 23 and Anc. 23 and Anc test a different set of genes, although they mostly overlap. For my wife’s test from both 23 and Anc the corresponding Prom reports were about 85% the same for the 40 most significant hits (Prom magnitude 2.5 and above). There were 5 or 6 unique hits in the top 40 for each report. I judge that the unique hits were about equally important, between 23 and Anc – none were critical.[Nov 2017 Update] In October 2017 I resubmitted by 2016 23 test to Prom. About 15% of the hits were changed. A couple unusual hits were deleted. A very significant change was that one gene comment changed from ‘increased risk of Type 1 diabetes’ to ’18x risk of Type 1 diabetes’!!! I read up on this. It turns out that the genetic – diabetes risk/connection is currently a very hot and complex research topic. The relevant research report was published in 2017. My suggestion is to update your Prom report every year or two if there are concerns.USING PROMETHEASE – IMPORTANT – Use of general DNA analysis to identify general medical conditions is an emerging (not well developed) technology/business. My guess is that the info provided by Prom is perhaps 30% or so of what will be available in 10 years or so. I regard the info provide as indicative, definitely not complete and possibly incorrect (due to either testing error or interpretation error).Having said that, it is interesting, likely useful and potentially lifesaving. The information will be disturbing (negative), but in most cases not surprising. I think most people will be able to absorb the info without getting too stressed out. If you are a hypochondriac, this could be a problem. If you want a chance of good news, you can write down the stuff your are concerned about ahead of time, and then see if they actually shows up.My comments for using the report are:• Make sure you download a copy to your PC for future reference, don’t just look at it online.• After you figure out how to use the report, move the ‘0’ Magnitude slider up to a range of 2.5 or so. This will limit you to the top 40 or so hits. Then go down to the bottom of the report and hit the ‘2X’ bar a few times to see all the hits.• You can then hit the ‘Table’ button at the top and print a summary of the hits to help see the big picture. You can also open this table in Excel and modify/save it for a more useful table. If you do this, add a Frequency column if it’s not already there.• To me, after Magnitude, the most important factor is ‘Frequency’. This is what percentage of the target population has this condition. If its around 40% or higher, I think it’s already ‘dialed in’ to the normal medical process – it is something your doctor and the medical community will look for in any case. Most of the hits fall into this category. If it’s less than 10%, it’s likely not on your doctors radar screen and you will want to consider if it’s worth mentioning to your doctor.• The second most useful item is the relative increased risk in the item discussion. Recognize that the absolute risk is not provided – for example, the absolute risk might be 1 person in 100,000, so a 1.1 relative risk increase is almost meaningless. On the other hand I looked up AMD (Age Related Macular Degeneration-eye problems) on the internet; it affects 1 in 3 to 5 people by age 80, so 2x risk is really significant. Good to know this ahead of time.• After you assess the top 40, which takes a while, you can expand the Magnitude to it’s full range. Then click on ‘Topics’ and click on sub topics of interest and see if any common concerns emerge. Do the same for ‘Medical Conditions’. This seems like a lot of work but only takes an hour or 2 once you get started. For me the common themes seem to be heart disease, Alzheimer’s and Rheumatoid arthritis – none of which are a surprise.- When you find something that might be relevant you NEED to do supplemental research on the Internet. The Prom report is a brief and simple identification. Fuller understanding can significantly change (reduce?) your concern for the issue. Be aware that there are ‘hypochondriac’ web sites for some of these issues. I like to start with Wiki, Mayo Clinic and WebMD. Search for the Prom gene name ‘rs……..’. Then find out what the common term(s) for the gene is e.g. MTFHR and search for that. Write stuff down, gene names can be confusing.• Again, remember this is an emerging technology, so the results will change from year to year. I guess that in 10 years it will be a routine consideration in a physical.IMPORTANT. DO NOT use Prom results from Anc for Alzheimer’s. Anc almost always reports zero copies of the Alz APOE4 gene. Prom notes this in their report, but it’s carries a low Magnitude and is easy to miss. In Sept 2018 I did an Anc test and it returned (via Prom), Zero copies of the Alz gene. The Anc and Prom medical results were otherwise similar but slightly less extensive than 23 and Prom.

  8. R. Holzle

    Oct 2019 Update revises Promethease recommendation; Oct 2018 Update adds Alzheimer comments.I had DNA analysis from 23andme. My wife had DNA analysis from both Ancestry(Anc) and 23andme. This review is my comparison of the two. I now do not recommend secondary analysis of your results by Promethease, see further discussion at end of this review. Basically I like 23andme. For developing an ancestry tree, Ancestry.com is MUCH better IF you signup separately for Ancestry’s subscription search service. Do not use Anc & Promethease for Alzheimer’s – see discussion at end of this review.TAKING TEST and SIGNUP – Very similar test taking. 23’s signup was more secure. Anc’s was easier, but they automatically put my wife’s test on my previously existing Ancestry account.Waiting on RESULTS – Both send emails confirming sample receipt and when results were available. After logon, 23 provided step by step progress reports on the analysis process. The analysis process itself took about 10 days, including a holiday weekend. Total wait time was 3-4 weeks. Anc took 5 or so days longer than 23.WEB SITE SECURITY – 23 is better. 23 requires a typical logon and password to get to the site. Anc automatically remembers your logon and password and just opens up when you go to the site. However, actually downloading your DNA file from Anc requires a full sign-on and confirmation link via your e-mail..Ethnic Origin Analysis – I think 23 is more correct. Both 23 and Anc keep updating their Ethnic origin results. Note the results are only approximate considering the accuracy ranges provided.DNA RELATIVE IDENTIFICATION – Recognizing that allocation of relatives to 1st, 2nd and 3rd cousins is somewhat imprecise. For my wife, 23 identified 4 second cousins and about 32 third cousins. Anc identified 1 first cousin, 2 second cousins and 9 third cousins. 23 also has ‘cousins’ outside the USA (in my case in the UK) which are really valuable contacts for ancestry searching. The web site does not directly identify a cousin’s location but you can easily guess this from supplementary info optionally provided by the cousin on 23’s site.DNA RELATIVE CONTACT and ANALYSIS – Anc provides the e-mail for a contact and shared ancestors for each DNA relative. You get a lot more when you pay for their regular Ancestry services, see below. 23 provides an internal messaging application for communicating with contacts. The application works but is rudimentary and unsuitable for more than brief messages (especially with MS Edge); exchanging e-mail address’s after contact is more satisfying. Both have a couple levels of ‘sharing’ (aka privacy). Both have tools for grouping contacts.Anc provides a powerful tree searching tool IF you subscribe to the regular Ancestry service. This is expensive, in the range of $200/year, but less with special offers. Given the moderate ‘tools’ in their basic DNA service, I view their DNA analysis as an (effective) teaser for their subscription service. UPDATE: I did signup for the Ancestry services and they are great. Specifically, with a subscription their DNA site shows a contacts pedigree chart if that contact already has built an Anc family tree. This is MASSIVELY better than 23’s unsorted list of surnames. When you search for a particular name it searches all of the connected family trees – this is exceptionally useful.MEDICAL INFO – Anc provides no medical info. In late 2016 23 had two test options – $100 for just the ancestry service and $200 for ancestry plus medical. As of Sept 2018, 23 provides FDA approved reports on your risk of 9 medical conditions, including Alzheimer’s, plus several genetic carrier reports. Their discussion/explanation of your risks for these conditions is specifically approved by the FDA and is understandable, informative, and useful. [Update ANC now advertises health results – I have not tried this]If you are so inclined, you can participate (answer a lot of online questions) in 23’s medical research. This is probably 20 ten minute questions sessions. I did this and feel like it was useful for medical research.Analysis of you DNA results by Promethease, a third party service, provides some medical info.[October 2019 Update] In late 2019 Promethease was bought by MyHeritage, an Israeli Company. They have advised that they will use the DNA profiles downloaded to them for DNA ancestry searches, including searches by police departments. I personally am uncomfortable with this. Further in early 2019 Promethease stopped providing reports for a number of SNP’s potentially related to drug usage, apparently due to pressure from the FDA. These are among the MOST useful (actionable) results. For these reasons I think Promethease is now of substantially less value. Perhaps MyHeritage will reinstate the deleted SNP’s, but I doubt it. Use Promethease with caution. Note that I have NOT updated the remainder of the Prom discussion to reflect the above comments.CONNECTION to PROMETHEASE – Promethease (Prom) is a third party service that assess’s your detailed DNA results from either 23 or Anc and provides a detailed medical risk report. Go to the Prom site to get started. The download process is not too difficult. In Oct 2018 cost is $12 per report.PROMETHEASE RESULTS –Prom generates 20,000 or so reports (hits) from the 700,000 or so genes that are tested by 23 and Anc. 23 and Anc test a different set of genes, although they mostly overlap. For my wife’s test from both 23 and Anc the corresponding Prom reports were about 85% the same for the 40 most significant hits (Prom magnitude 2.5 and above). There were 5 or 6 unique hits in the top 40 for each report. I judge that the unique hits were about equally important, between 23 and Anc – none were critical.[Nov 2017 Update] In October 2017 I resubmitted by 2016 23 test to Prom. About 15% of the hits were changed. A couple unusual hits were deleted. A very significant change was that one gene comment changed from ‘increased risk of Type 1 diabetes’ to ’18x risk of Type 1 diabetes’!!! I read up on this. It turns out that the genetic – diabetes risk/connection is currently a very hot and complex research topic. The relevant research report was published in 2017. My suggestion is to update your Prom report every year or two if there are concerns.USING PROMETHEASE – IMPORTANT – Use of general DNA analysis to identify general medical conditions is an emerging (not well developed) technology/business. My guess is that the info provided by Prom is perhaps 30% or so of what will be available in 10 years or so. I regard the info provide as indicative, definitely not complete and possibly incorrect (due to either testing error or interpretation error).Having said that, it is interesting, likely useful and potentially lifesaving. The information will be disturbing (negative), but in most cases not surprising. I think most people will be able to absorb the info without getting too stressed out. If you are a hypochondriac, this could be a problem. If you want a chance of good news, you can write down the stuff your are concerned about ahead of time, and then see if they actually shows up.My comments for using the report are:• Make sure you download a copy to your PC for future reference, don’t just look at it online.• After you figure out how to use the report, move the ‘0’ Magnitude slider up to a range of 2.5 or so. This will limit you to the top 40 or so hits. Then go down to the bottom of the report and hit the ‘2X’ bar a few times to see all the hits.• You can then hit the ‘Table’ button at the top and print a summary of the hits to help see the big picture. You can also open this table in Excel and modify/save it for a more useful table. If you do this, add a Frequency column if it’s not already there.• To me, after Magnitude, the most important factor is ‘Frequency’. This is what percentage of the target population has this condition. If its around 40% or higher, I think it’s already ‘dialed in’ to the normal medical process – it is something your doctor and the medical community will look for in any case. Most of the hits fall into this category. If it’s less than 10%, it’s likely not on your doctors radar screen and you will want to consider if it’s worth mentioning to your doctor.• The second most useful item is the relative increased risk in the item discussion. Recognize that the absolute risk is not provided – for example, the absolute risk might be 1 person in 100,000, so a 1.1 relative risk increase is almost meaningless. On the other hand I looked up AMD (Age Related Macular Degeneration-eye problems) on the internet; it affects 1 in 3 to 5 people by age 80, so 2x risk is really significant. Good to know this ahead of time.• After you assess the top 40, which takes a while, you can expand the Magnitude to it’s full range. Then click on ‘Topics’ and click on sub topics of interest and see if any common concerns emerge. Do the same for ‘Medical Conditions’. This seems like a lot of work but only takes an hour or 2 once you get started. For me the common themes seem to be heart disease, Alzheimer’s and Rheumatoid arthritis – none of which are a surprise.- When you find something that might be relevant you NEED to do supplemental research on the Internet. The Prom report is a brief and simple identification. Fuller understanding can significantly change (reduce?) your concern for the issue. Be aware that there are ‘hypochondriac’ web sites for some of these issues. I like to start with Wiki, Mayo Clinic and WebMD. Search for the Prom gene name ‘rs……..’. Then find out what the common term(s) for the gene is e.g. MTFHR and search for that. Write stuff down, gene names can be confusing.• Again, remember this is an emerging technology, so the results will change from year to year. I guess that in 10 years it will be a routine consideration in a physical.IMPORTANT. DO NOT use Prom results from Anc for Alzheimer’s. Anc almost always reports zero copies of the Alz APOE4 gene. Prom notes this in their report, but it’s carries a low Magnitude and is easy to miss. In Sept 2018 I did an Anc test and it returned (via Prom), Zero copies of the Alz gene. The Anc and Prom medical results were otherwise similar but slightly less extensive than 23 and Prom.

  9. Eileen

    This DNA test from 23andMe gives you a huge amount of raw data. If you’re looking for medical information (not just ancestry), you are getting your money’s worth. However, due to FDA regulations, they aren’t allowed to interpret it for you beyond some very basic (and frankly unhelpful) reports. This is true for all DNA testing companies when it comes to medical information. The good news is that you can upload your 23andMe data to other websites and receive detailed reports. Promethease.com gives you detailed reporting for just $5 – everything from vulnerabilities to diseases, to genes associated with personality traits. Another commenter mentioned the MTHFR mutations, which are associated with many chronic illnesses. Geneticgenie.org will run your 23andMe results specifically related to these genes, and the report is free. And if you can afford it, the best way to interpret your results is to make an appointment with a genetic counselor, who you can find through NSGC.org. So, you’re paying for the data with this test, and it’s just a few extra steps to understand the data.

  10. Eileen

    This DNA test from 23andMe gives you a huge amount of raw data. If you’re looking for medical information (not just ancestry), you are getting your money’s worth. However, due to FDA regulations, they aren’t allowed to interpret it for you beyond some very basic (and frankly unhelpful) reports. This is true for all DNA testing companies when it comes to medical information. The good news is that you can upload your 23andMe data to other websites and receive detailed reports. Promethease.com gives you detailed reporting for just $5 – everything from vulnerabilities to diseases, to genes associated with personality traits. Another commenter mentioned the MTHFR mutations, which are associated with many chronic illnesses. Geneticgenie.org will run your 23andMe results specifically related to these genes, and the report is free. And if you can afford it, the best way to interpret your results is to make an appointment with a genetic counselor, who you can find through NSGC.org. So, you’re paying for the data with this test, and it’s just a few extra steps to understand the data.

  11. Lightsout303

    Decided to buy these as a stocking stuffer for my wife and I in Christmas of 2018. The amount of information is incredible, for one of the sections connects you with anyone who shares your DNA, it could be 2nd-5th cousins, aunts, uncles or anyone in your family or DNA related that has taken this test. It builds a data section for your DNA relatives. That’s where I found out I had a 21 year old son…he had taken the test to figure out who he was, not realizing I had taken it also! I was able to reach out to him through the app and it was amazing to meet him! Therefore, if you were a wild guy like myself in your early 20’s…you’ve been warned 🙂 We now have a great relationship and I’m a proud father of 4!

  12. Lightsout303

    Decided to buy these as a stocking stuffer for my wife and I in Christmas of 2018. The amount of information is incredible, for one of the sections connects you with anyone who shares your DNA, it could be 2nd-5th cousins, aunts, uncles or anyone in your family or DNA related that has taken this test. It builds a data section for your DNA relatives. That’s where I found out I had a 21 year old son…he had taken the test to figure out who he was, not realizing I had taken it also! I was able to reach out to him through the app and it was amazing to meet him! Therefore, if you were a wild guy like myself in your early 20’s…you’ve been warned 🙂 We now have a great relationship and I’m a proud father of 4!

  13. AmyD

    When I bought these for all my sibling for Christmas I couldn’t figure out why my mother was upset at me for getting them. She tried so hard to convince us all that the government was trying to get their hands on a sample of everyone’s DNA. When that didn’t persuade us from doing our test, she then tried to just convince us that one of us 4 kids should do it since we all have the same blood. We couldn’t figure out why she was getting so mad at us when we refused her ideas, her and my father went to their room and got into a huge fight.I think at least one of us is the mailman’s child.It was Karen.

  14. AmyD

    When I bought these for all my sibling for Christmas I couldn’t figure out why my mother was upset at me for getting them. She tried so hard to convince us all that the government was trying to get their hands on a sample of everyone’s DNA. When that didn’t persuade us from doing our test, she then tried to just convince us that one of us 4 kids should do it since we all have the same blood. We couldn’t figure out why she was getting so mad at us when we refused her ideas, her and my father went to their room and got into a huge fight.I think at least one of us is the mailman’s child.It was Karen.

  15. Ken

    Excellent, but I would get the $99 kit over the $199 one. Then go to Promethease.com and dna.land.com and import your results (when their available from 23andMe), For $5.00 they give you loads of medical and other misc. insights from your genetic information. Importing is quick and easy, do it right from the Promethease website (links to 23andMe directly and grabs your data. dna.land requires you to upload data yourself). Just be sure to download a copy of the final results to your computer for future reference (as Promethease will automatically delete information from their servers after 4 months). DNA.LAND is free (it’s a research project) well worth the extra effort and produces some more interesting results.

  16. Ken

    Excellent, but I would get the $99 kit over the $199 one. Then go to Promethease.com and dna.land.com and import your results (when their available from 23andMe), For $5.00 they give you loads of medical and other misc. insights from your genetic information. Importing is quick and easy, do it right from the Promethease website (links to 23andMe directly and grabs your data. dna.land requires you to upload data yourself). Just be sure to download a copy of the final results to your computer for future reference (as Promethease will automatically delete information from their servers after 4 months). DNA.LAND is free (it’s a research project) well worth the extra effort and produces some more interesting results.

  17. Mikvikpik

    It’s exactly what you’d expect and at the same time you can’t foresee it at all. When you listen to your parents and grandparents talk about your heritage and history you learn to believe it as truth and it is and always will be. Until you take this test. Do your research on ancestry.com or heritage.com first. Even then it’ll still catch you off guard. Going through the list I’ve always known that I’m Filipino, between me and my cousin it’s our greatest party trick because I’m white guy white and he is like Hawaiian brown. But we’re first cousins. But I loved seeing the percentage. 29% is definitely more than a quarter and it feels good to know that I can take my most memorable heritage growing up with me in confidence. All the next ones going down are a little harder to distinguish because I was told I was Polish, Italian, and some Swedish. The broadly European covers some of that and the Eastern Europe is there for Polish. the rest gets lost in translation, but is amazing to see where my history comes from. I’m hoping it’ll lead into some other cool heritage discoveries.The health stuff is kinda cool, but for me it’s mostly a puff piece to look at. I’ll take a shallow sigh of relief because I don’t have any known traits of genetic diseases that it checks, but it’s not an exhaustive search that they do and they warn you that there still might be a chance. Most everything else is for research that they use to ask you questions to compare to your lifestyle choices. It’s still in it’s infancy, but it’s growing in popularity and is slowly hedging from novelty item to talk about at parties to serious research to take to your doctor.The bottom line is this- I did it because I was genuinely interested it what information was there and that I held in my genes. I have no regrets and look forward to where it will head in the future. I’d compare it to a cool Nokia brick phone of 2006 to say that I was one of the first to try it, but can’t wait for the 2020 iPhone edition stuff with all the cool features.Last Note: Make sure it’s liquid spit and not bubbles that go up to the fill line. It’s a little messy but important.

  18. Mikvikpik

    It’s exactly what you’d expect and at the same time you can’t foresee it at all. When you listen to your parents and grandparents talk about your heritage and history you learn to believe it as truth and it is and always will be. Until you take this test. Do your research on ancestry.com or heritage.com first. Even then it’ll still catch you off guard. Going through the list I’ve always known that I’m Filipino, between me and my cousin it’s our greatest party trick because I’m white guy white and he is like Hawaiian brown. But we’re first cousins. But I loved seeing the percentage. 29% is definitely more than a quarter and it feels good to know that I can take my most memorable heritage growing up with me in confidence. All the next ones going down are a little harder to distinguish because I was told I was Polish, Italian, and some Swedish. The broadly European covers some of that and the Eastern Europe is there for Polish. the rest gets lost in translation, but is amazing to see where my history comes from. I’m hoping it’ll lead into some other cool heritage discoveries.The health stuff is kinda cool, but for me it’s mostly a puff piece to look at. I’ll take a shallow sigh of relief because I don’t have any known traits of genetic diseases that it checks, but it’s not an exhaustive search that they do and they warn you that there still might be a chance. Most everything else is for research that they use to ask you questions to compare to your lifestyle choices. It’s still in it’s infancy, but it’s growing in popularity and is slowly hedging from novelty item to talk about at parties to serious research to take to your doctor.The bottom line is this- I did it because I was genuinely interested it what information was there and that I held in my genes. I have no regrets and look forward to where it will head in the future. I’d compare it to a cool Nokia brick phone of 2006 to say that I was one of the first to try it, but can’t wait for the 2020 iPhone edition stuff with all the cool features.Last Note: Make sure it’s liquid spit and not bubbles that go up to the fill line. It’s a little messy but important.

  19. A. Roos

    I’m a sperm donor baby. I followed the instructions, spit in the vial, and found my genetic father. Life is weird but good. Thanks 23andme.

  20. A. Roos

    I’m a sperm donor baby. I followed the instructions, spit in the vial, and found my genetic father. Life is weird but good. Thanks 23andme.

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